147098-20-2|Rosuvastatin Calcium| 瑞舒伐他汀钙 |瀚香生物科技...

来自 : www.biochempartner.com/147098- 发布时间：2021-03-25

Rosuvastatin is relatively hydrophilic and is highly selective for hepatic cells; its uptake is mediated by the liver-specific organic anion transporter OATP-C. Rosuvastatin is a high-affinity substrate for OATP-C with apparent association constant of 8.5 μM.Rosuvastatin inhibits cholesterol biosynthesis in rat liver isolated hepatocytes with IC50 of 1.12 nM. Rosuvastatin causes approximately 10 times greater increase of mRNA of LDL receptors than pravastatin. Rosuvastatin (100 μM) decreases the extent of U937 adhesion to TNF-α-stimulated HUVEC. Rosuvastatin inhibits the expressions of ICAM-1, MCP-1, IL-8, IL-6, and COX-2 mRNA and protein levels through inhibition of c-Jun N-terminal kinase and nuclear factor-kB in endothelial cells.
AMPA/NMDA ATPase BCRP Calcium Channel CFTR Chloride Channel CRAC Channel CRM1 EAAT GABA Receptor GlyT HCN Channel MCT Monoamine Transporter nAChR NCX NKCC...CAS 147098-20-2, 147098-20-2, 瑞舒伐他汀钙,瑞舒伐他汀钙,罗舒伐他汀钙,超级他汀钙,瑞舒伐他汀钙现货供应,瑞舒伐他汀钙大批量大折扣,瑞舒伐他汀钙定制合成,瑞舒伐他汀钙批量折扣,Rosuvastatin Calcium, S-4522, S 4522, S4522, ZD 4522, ZD-4522, ZD4522, ZD 4522 calcium salt,Rosuvastatin hemicalcium, ZD 4522 Calcium,CRESTOR,Rosuvastatin Calcium SaltRosuvastatin Calcium is a competitive inhibitor of HMG-CoA reductase with IC50 of 11 nM.147098